Phosphoinositide 3-kinase (PI3K) and nutrient sensing mTOR (mammalian target of rapamycin) pathways control T lymphocyte trafficking
نویسندگان
چکیده
1Department of Cell Biology and Immunology, University of Dundee, DD1 5EH, UK 2Immune Cell Biology, The National Institute for Medical Research, London, NW7 1AA, UK 3Division of Molecular Physiology, University of Dundee, DD1 5EH, UK 4Department of Medical Biochemistry and Immunology, Cardiff University, CF14 4XN, UK 5Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB2 4AT, UK 6Department of Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands 7Department of Immunology Discovery, Genentech Inc., South San Francisco, California CA 94080, USA
منابع مشابه
Eupafolin ameliorates lipopolysaccharide-induced cardiomyocyte autophagy via PI3K/AKT/mTOR signaling pathway
Objective(s): Eupafolin, a major active component of Eupatorium perfoliatum L., has anti-inflammatory and anti-oxidant properties. Lipopolysaccharide (LPS) is responsible for myocardial depression. A line of evidences revealed that LPS induces autophagy in cardiomyocytes injury. This study aims to evaluate the effects of eupafolin on LPS-induced cardiomyocyte autophagy...
متن کاملPhosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration.
The established role for phosphatidylinositol (3,4,5) triphosphate (PI(3,4,5)P3) signaling pathways is to regulate cell metabolism. More recently it has emerged that PI(3,4,5)P3 signaling via mammalian target of rapamycin and Foxo transcription factors also controls lymphocyte trafficking by determining the repertoire of adhesion and chemokine receptors expressed by T lymphocytes. In quiescent ...
متن کاملThe Expanding Role of the mammalian Target of Rapamycin Complex 2 (mTORC2) in Cellular Metabolism
The mammalian Target of Rapamycin (mTOR) nutrient-sensing pathway plays a fundamental role in cell growth, and proliferation, as well as in tumor metabolism. mTOR is the catalytic subunit that nucleates two functionally and structurally distinct complexes namely; mTORC1 (mammalian Target of Rapamycin Complex 1) and mTORC2 (mammalian Target of Rapamycin Complex 2). mTORC1 integrates inputs from ...
متن کاملEvidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice.
How growth hormone (GH) stimulates protein synthesis is unknown. Phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathways balance anabolic and catabolic activities in response to nutrients and growth factor signaling. As a test of GH signaling, immunoassays of two downstream translation regulatory proteins were compared in ad libitum-fed 2-month-old normal ...
متن کاملRegulation of class III (Vps34) PI3Ks.
The class III PI3K (phosphoinositide 3-kinase), Vps34 (vacuolar protein sorting 34), was first identified as a regulator of vacuolar hydrolase sorting in yeast. Unlike other PI3Ks, the Vps34 lipid kinase specifically utilizes phosphatidylinositol as a substrate, producing the single lipid product PtdIns3P. While Vps34 has been studied for some time in the context of endocytosis and vesicular tr...
متن کامل